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:: Volume 20, Issue 1 (Iranian Journal of Ophthalmology 2008) ::
2008, 20(1): 42-47 Back to browse issues page
Comparison of the Effect of Adjuvant 5-Fluorouracil, Low Molecular Weight Heparin and Daunomycin in Combination with Triamcinolone during Vitrectomy in Advanced Retinal Detachment
Ahmad Mirshahi Dr. *, Habib Dezhagah Dr., AliReza Lashay Dr., Ali Tabatabaei Dr., Mohammad-Sadegh Farahvash Dr., Hooshang Faghihi Dr., Ali Abdollahi Dr., Reza Karkhaneh Dr., Morteza Movasat Dr., Mohammad Riazi-Esfahani Dr.
, mirshahi@tums.ac.ir
Abstract:   (19124 Views)

Purpose: To compare the success rate of adjunctive 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH), and daunomycin in combination with triamcinolone during vitrectomy in eyes with retinal detachment (RD) and proliferative vitreoretinopathy (PVR).

Methods: In this prospective randomized clinical trial, 69 eyes from 69 patients with RD and PVR (grade B or C) randomized to 3 groups. Group 1: received 5-FU and LMWH (200 microgram/ml 5-FU and 5 IU/ml LMWH, Fragmin) group 2: received daunomycin (0.5 mg) in
500 cc infusion fluid and group 3: control group. In all patients, 0.1 cc intravitreal triamcinolone was used during vitrectomy. The patients visited on day 1, week 1, month 1, 3 and 6. Best corrected visual acuity (BCVA) and retinal status compared in the 3 groups.

Results: Complete data were available for 60 out of 69 patients. Thirty five patients (58.3%) were male and 25 patients (41.7%) were female. The patient age range was 19-84 years and the mean age was 49. The groups did not have significant difference in age, sex, duration of detachment, severity of PVR, preoperative visual acuity (V/A), lens status, type of tamponade and encircling band and buckle. Postoperative V/A and retina status also was the same in the 3 groups.

Conclusion: Perioperative infusion of 5-FU, LMWH and daunomycin does not significantly increase the success rate of patients with RD and PVR comparing to control group. Although visual acuity improvement and retina reattachment rate in group 1 and 2 were better than control group, but statistical analysis failed to show significant difference between the 3 groups.

 

Iranian Journal of Ophthalmology 200820(1):42-47
Keywords: retinal detachment, proliferative vitreoretinopathy, daunomycin, 5-Fluorouracil, low molecular weight heparin, deep vitrectomy
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Type of Study: Original | Subject: General
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Mirshahi A, Dezhagah H, Lashay A, Tabatabaei A, Farahvash M, Faghihi H, et al . Comparison of the Effect of Adjuvant 5-Fluorouracil, Low Molecular Weight Heparin and Daunomycin in Combination with Triamcinolone during Vitrectomy in Advanced Retinal Detachment. Iranian Journal of Ophthalmology. 2008; 20 (1) :42-47
URL: http://irjo.org/article-1-114-en.html


Volume 20, Issue 1 (Iranian Journal of Ophthalmology 2008) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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