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:: Volume 19, Issue 3 (Iranian Journal of Ophthalmology 2007) ::
2007, 19(3): 22-28 Back to browse issues page
Tissue Plasminogen Activator versus Aspirin in Central Retinal Vein Occlusion
Mohammad-Sadegh Farahvash Dr., Masood Aghsaie-Fard Dr. *, Ahmad Mirshahi Dr., Alireza Lashay Dr., Ahmad Javadian Dr., Hooshang Faghihi Dr., Marzieh Moradimoghadam Dr., Seyed-Ali Tabatabaei Dr., Reza Karkhaneh Dr., Zahra Aalami-Harandi Dr.
, masood219@yahoo.co.uk
Abstract:   (17004 Views)

Purpose: To compare the effect of tissue plasminogen activator (TPA) and aspirin in patients with central retinal vein occlusion.

Methods: A prospective interventional study was conducted on patients with central retinal vein occlusion of less than 28 days' duration. Patients in the TPA group received 100 μg intravitreal tissue plasminogen activator and the patients who declined intravitreal injection were considered as Aspirin group. Patients were followed up for 6 months.

Results: sixty five patients were enrolled, 19 in the TPA group and 46 in the Aspirin group. The mean 6-month change in visual acuity for TPA-treated patients was -0.29±0.42 (range: -1.4 to +0.5) while in the Aspirin group, it was 0.28±0.79 with a range of -1 to +2.5. TPA group had a significantly better visual improvement in comparison to Aspirin group (P< 0.0005).

Conclusion: Intravitreal tissue plasminogen activator can be injected safely and easily. Patients treated with intravitreal tissue plasminogen activator within 28 days of the onset of central retinal vein occlusion are more likely to improve visual acuity.


Iranian Journal of Ophthalmology 200619(3):22-28
Keywords: Central Retinal Vein Occlusion, Tissue Plasminogen Activator, Visual Acuity, Neovascularization of Iris
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Type of Study: Original | Subject: General
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Farahvash M, Aghsaie-Fard M, Mirshahi A, Lashay A, Javadian A, Faghihi H, et al . Tissue Plasminogen Activator versus Aspirin in Central Retinal Vein Occlusion. Iranian Journal of Ophthalmology. 2007; 19 (3) :22-28
URL: http://irjo.org/article-1-145-en.html

Volume 19, Issue 3 (Iranian Journal of Ophthalmology 2007) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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