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:: Volume 22, Issue 3 (Iranian Journal of Ophthalmology 2010) ::
2010, 22(3): 23-28 Back to browse issues page
Multifocal Electroretinography Assisted Comparison of Macular Photocoagulation versus Macular Photocoagulation and Intravitreal Bevacizumab Injection in Diabetic Macular Edema
Ali Abdollahi Dr., Morteza Movassat Dr. *, Mehdi Nili Ahmadabadi Dr., Maryam Abdollahi, Abasat Bashiri Dr.
, movassat456@yahoo.com
Abstract:   (11723 Views)

Purpose : To evaluate the effect of intraviteral bevacizumab (IVB) in diabetic macular edema (DME), using multifocal electroretinography (mfERG)

Methods : Sixty-four eyes of 32 patients with bilateral symmetric clinically significant macular edema (CSME) were included in the study. After taking a baseline mfERG, macular photocoagulation (MPC) was done in all eyes. After 7 days, 1.25 mg of bevacizumab was randomly injected in one eye of each patient and the other eye assigned for sham injection. mfERG was repeated 8 weeks after injection, and changes in visual acuity and mfERG compared in two groups.

Results : The mean best corrected visual acuities (BCVAs) at baseline were 0.55 in IVB group and 0.51 in control group and at 8th week were 0.41 and 0.53 respectively, also the amplitude and implicit time showed significant improvement in mfERG. Significant improvement in visual acuity and amplitude of waves of mfERG were observed compared with sham group.

Conclusion : IVB injection can augment the effect of MPC in DME and can be used as an adjunctive treatment in these cases.

  

Iranian Journal of Ophthalmology 201022(3):23-28 © 2010 by the Iranian Society of Ophthalmology
Keywords: Bevacizumab, Multifocal Electroretinography, Amplitude, Implicit Time, Diabetic Macular Edema, Photocoagulation
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Type of Study: Original | Subject: General
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Abdollahi A, Movassat M, Nili Ahmadabadi M, Abdollahi M, Bashiri A. Multifocal Electroretinography Assisted Comparison of Macular Photocoagulation versus Macular Photocoagulation and Intravitreal Bevacizumab Injection in Diabetic Macular Edema. Iranian Journal of Ophthalmology. 2010; 22 (3) :23-28
URL: http://irjo.org/article-1-374-en.html


Volume 22, Issue 3 (Iranian Journal of Ophthalmology 2010) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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