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:: Volume 22, Issue 3 (Iranian Journal of Ophthalmology 2010) ::
2010, 22(3): 57-60 Back to browse issues page
Toxic Effect of Intravitreal Carboplatin Detected by Flattened Electeroretinogram in A Patient with Retinoblastoma Treated by Chemoreduction and Local Treatments
Reza Karkhaneh Dr., Bijan Pourmostadam Dr., Fariba Ghassemi Dr. *, Morteza Movassat Dr., Ramak Roohipoor Dr., Mehdi Nili Ahmadabadi Dr.
, fariba.ghassemi@gmail.com
Abstract:   (12799 Views)

Purpose : The first report of electroretinographic changes following the intravitreal injection of carboplatin in a patient with retinoblastoma

Case report : Recurrent tumors after chemoreduction and adjunctive local treatment in a case of familial unilateral retinoblastoma, group C, was treated with intravitreal carboplatin (10 µg) injections.

Results : The tumor was regressed after 3 injections. Flat electeroretinogram (ERG) amplitude was noted following the intravitreal injection of carboplatin. After nearly one year tumor-free period in this case, visual acuity (VA) in the affected eye was 20/800 despite a flat ERG.

Conclusion : Intravitreal carboplatin can effectively treat intraretinal tumor recurrences but de-novo tumors can be produced causing therapeutic problems. Intravitreal injections of carboplatin can cause retinal toxicity and flat ERG.

  

Iranian Journal of Ophthalmology 201022(3):57-60 © 2010 by the Iranian Society of Ophthalmology
Keywords: Retinoblastoma, Chemoreduction, Intravitreal Carboplatin, Flattened Electeroretinogram
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Type of Study: Case report | Subject: General
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Karkhaneh R, Pourmostadam B, Ghassemi F, Movassat M, Roohipoor R, Nili Ahmadabadi M. Toxic Effect of Intravitreal Carboplatin Detected by Flattened Electeroretinogram in A Patient with Retinoblastoma Treated by Chemoreduction and Local Treatments. Iranian Journal of Ophthalmology. 2010; 22 (3) :57-60
URL: http://irjo.org/article-1-380-en.html


Volume 22, Issue 3 (Iranian Journal of Ophthalmology 2010) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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