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:: Volume 23, Issue 2 (Iranian Journal of Ophthalmology 2011) ::
2011, 23(2): 11-18 Back to browse issues page
Orbital Doppler Evaluation of Blood Flow Velocities in Optic Neuritis
Mehdi Karami Dr., Mohsen Janghorbani Dr. *, Alireza Dehghani Dr., Maryam Riahinejad Dr.
, janghorbani@yahoo.com
Abstract:   (11579 Views)

Purpose : To evaluate orbital blood flow velocities and optic nerve diameter with Doppler and gray-scale sonography in patients with acute unilateral optic neuritis (ON)

Methods : Orbital Doppler and gray-scale sonography was performed in 46 eyes of 23 patients aged 19-47 with acute unilateral ON. ON was diagnosed by an ophthalmologist on the basis of clinical presentation, presence of decreased visual acuity (VA) and assessment of visual evoked potentials (VEP). The peak systolic (PSV) and end-diastolic (EDV) blood flow velocities and resistance and pulsatile indices (RI, PI) of the ophthalmic artery (OA), central retinal and posterior ciliary arteries (CRA, PCAs) and optic nerve diameter were measured in both eyes. We compared results from affected and unaffected eyes using the paired T-test. The area under the receiver-operating characteristic (ROC) curves was used to assess diagnosis of ON on the basis of measured blood flow parameters of the OA, CRA and PCAs and optic nerve diameter.

Results : Optic nerve diameter in eyes with ON was significantly higher than that of the control eyes (P<0.001). The mean (SD) optic nerve diameter was 4.1 (0.8) mm in affected eyes and 3.0 (0.4) mm in unaffected eyes (P<0.001). There were no differences in average PSV, EDV, RI and PI of OA and CRA between affected and unaffected eyes (P>0.05). The mean RI in the PCAs (P<0.05) was slightly lower in the eyes with ON than in the contralateral eyes. The area under the ROC curves was 0.928 for optic nerve diameter.

Conclusion : Optic nerve diameter was related to ON, but orbital blood flow parameters were not.


Iranian Journal of Ophthalmology 201123(2):11-18 © 2011 by the Iranian Society of Ophthalmology
Keywords: Blood Flow Parameters, Doppler Sonography, Ophthalmic Artery, Optic Nerve Diameter, Optic Neuritis
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Type of Study: Original | Subject: General
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Karami M, Janghorbani M, Dehghani A, Riahinejad M. Orbital Doppler Evaluation of Blood Flow Velocities in Optic Neuritis. Iranian Journal of Ophthalmology. 2011; 23 (2) :11-18
URL: http://irjo.org/article-1-464-en.html

Volume 23, Issue 2 (Iranian Journal of Ophthalmology 2011) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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