[Home ] [Archive]   [ فارسی ]  
:: Volume 23, Issue 2 (Iranian Journal of Ophthalmology 2011) ::
2011, 23(2): 51-59 Back to browse issues page
Histopathologic Risk Factors of Retinoblastoma: A Retrospective Study of 104 Enucleated Eyes
Han Yue Dr., Jiang Qian Dr. * , Kang Xue Dr., Yingwen Bi Dr., Rongjia Chen Dr., Yinan Han Dr., Yifei Yuan Dr.
, qianjiang58@163.com
Abstract:   (10330 Views)

Purpose : To introduce a novel classification system for the extent of choroid invasion and to analyze the incidence of histopathologic risk factors (HRFs) in the patients with retinoblastoma in China

Methods : The clinical data of 104 enucleated eyes diagnosed with retinoblastoma were retrospectively reviewed, and the pathological re-examination of the enucleated eyes was conducted.

Results : Overall, the HRFs were present in 53% of the 104 eyes. For choroid infiltration, type 1 was observed in 38 eyes as isolated, sporadic tumor cells, or suspected tumor cells with no obvious choroid thickening type 2 in 26 eyes, as localized nest-like or nidulant tumor cells without obvious choroid thickening and type 3 in 25 eyes, as lumpish, massive or dense invasion with or without obvious choroid thickening. The mean follow-up period was 27.6 months (median, 24.9 range, 8.3-65.7). During the course of the study, four patients died of recurrence or metastasis. Statistically significant differences between the proportional mortality ratios were observed in choroidal infiltration of Type 3 (P=0.003), invasion of postlamina (P=0.033), sclera (P=0.003), and optic nerve resection line (P=0.005) cases. Based on univariate and multivariate analysis, leukocoria was negatively correlated with HRFs (P=0.001, OR=0.21 P=0.010, OR=0.25).

Conclusion : Clinically, the novel classification system for the extent of choroid invasion could function as a practical definition for choroid infiltration, and the HRFs are present in a significant proportion of patients enucleated for retinoblastoma in China.

  

Iranian Journal of Ophthalmology 201123(2):51-59 © 2011 by the Iranian Society of Ophthalmology
Keywords: Histopathology, Histopathologic Risk Factors, Retinoblastoma, China
Full-Text [PDF 386 kb]   (2076 Downloads)    
Type of Study: Original | Subject: General
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yue H, Qian J, Xue K, Bi Y, Chen R, Han Y et al . Histopathologic Risk Factors of Retinoblastoma: A Retrospective Study of 104 Enucleated Eyes. Iranian Journal of Ophthalmology. 2011; 23 (2) :51-59
URL: http://irjo.org/article-1-470-en.html


Volume 23, Issue 2 (Iranian Journal of Ophthalmology 2011) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3638