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:: Volume 25, Issue 2 (Iranian Journal of Ophthalmology 2013) ::
2013, 25(2): 115-122 Back to browse issues page
Comparison of Retinal Nerve Fiber Layer Profile in Subjects with Myopia and Emmetropia Using Scanning Laser Polarimetry
Reza Zarei Dr. *, Ramin Daneshvar Dr., Mohammad Soleimani Dr., Mohammad Razzaghi Dr., Heidar Amini Dr., Masoud Mohammadi Dr., Sasan Moghimi Dr., Yadollah Eslami Dr., Ghasem Fakhraie Dr., Seyed Ali Tabatabaei Dr.
, rzareia@yahoo.com
Abstract:   (12559 Views)

Purpose : To compare retinal nerve fiber layer (RNFL) profile in subjects with myopia and emmetropia using GDx variable corneal compensator (VCC)

Methods : Besides ophthalmologic standard examination (refraction, visual acuity and slit-lamp examination, applanation tonometry, and funduscopy), perimetry and scanning laser polarimetry (SLP) were performed. 171 healthy age-matched subjects with low to high myopia (90 subjects) and emmetropia (81 subjects) underwent RNFL analysis by means of GDx VCC. The mean value of each parameter was compared in myopic and emmetropic eyes.

Results : Mean myopia was 3.43±1.19 diopter (D) (range, -0.50 to -6.50). Except for ratio parameters, RNFL parameters were significantly lower in myopic patients. TSNIT standard deviation (p=0.026), nerve fiber indicator (NFI) (p=0.027), superior/nasal (p<0.0001), max modulation (p=0.003), ellipse modulation (p=0.0244) and Symmetry (p=0.028) were higher in myopic group. In both groups, all of RNFL measurements were within the normal range. There was a gradual decrease in RNFL thickness associated with aging in myopic patients (simple regression analysis, p<0.05). There was also a gradual decrease in temporal-superior-nasal-inferior thickness (TSNIT) average and superior maximum with increasing degree of myopia (simple regression analysis, p<0.05).

Conclusion : RNFL thicknesses gradually decreased with increasing age in myopic patients. Patients with myopia had significantly lower RNFL thickness than normal subjects and, although weakened by wide age range of myopic group, there was a linear negative correlation between severity of myopia and RNFL thickness in myopic patients.


Iranian Journal of Ophthalmology 201325(2):115-122 © 2013 by the Iranian Society of Ophthalmology

Keywords: Myopia, Emmetropia, Retinal Nerve Fiber Layer, Scanning Laser Polarimetry, GDx
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Type of Study: Original | Subject: Vitreoretinal
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Zarei R, Daneshvar R, Soleimani M, Razzaghi M, Amini H, Mohammadi M, et al . Comparison of Retinal Nerve Fiber Layer Profile in Subjects with Myopia and Emmetropia Using Scanning Laser Polarimetry. Iranian Journal of Ophthalmology. 2013; 25 (2) :115-122
URL: http://irjo.org/article-1-813-en.html

Volume 25, Issue 2 (Iranian Journal of Ophthalmology 2013) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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