[Home ] [Archive]   [ فارسی ]  
:: Volume 25, Issue 4 (Iranian Journal of Ophthalmology 2013) ::
2013, 25(4): 284-287 Back to browse issues page
Lacritin Level in Tear Film of Rheumatoid Arthritis Patients
Rana Sorkhabi *, Amir Ghorbanihaghjo , Mehrnoosh Ghasemi , Alireza Khabazi , Mohammadhosein Ahoor
Abstract:   (7378 Views)

Purpose : The main ocular manifestation of rheumatoid arthritis is dry eye. Lacritin is a secreted glycoprotein of tear and when applied topically in rabbits, it increased the volume of basal tear secretion. So the aim of this study was to compare Lacritin level in rheumatoid arthritis (RA) and control group.

Methods : This cross-sectional study was done on 40 patients with RA and 48 healthy subjects as a control group. In all participants, tear break-up time (TBUT) and Schirmer test with anesthesia were accomplished. Tear samples were collected directly from the inferior lateral tear meniscus and were immediately stored at -80 ° C until use. Lacritin level of tears were assessed by enzyme- linked immunosorbent assay.

Results : The mean age of participants was 44.7±16.3 and 43.3±18 years, respectively (p=0.70). Lacritin level in RA group (19.6±23.1 ng/ml) was significantly lower (31.9±23.3 ng/ml) than control (p=0.008). Pearson correlation between Lacritin level and TBUT, Schirmer value, ESR, and high-sensitivity C-creative protein (hs-CRP) in RA patients were not significant with p=0.27, 0.67, 0.09 and 0.07 accordingly.

Conclusion : In early stages of RA in spite of normal tear production, Lacritin level decreased, however there is not any correlation between Lacritin level and TBUT, Schirmer value, ESR, and hs-CRP in these patients.

 

Iranian Journal of Ophthalmology 201325(4):284-287 © 2013 by the Iranian Society of Ophthalmology

Keywords: Lacritin, Rheumatoid Arthritis, Tear Film
Full-Text [PDF 211 kb]   (1285 Downloads)    
Type of Study: Original | Subject: Vitreoretinal
Add your comments about this article
Your username or Email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sorkhabi R, Ghorbanihaghjo A, Ghasemi M, Khabazi A, Ahoor M. Lacritin Level in Tear Film of Rheumatoid Arthritis Patients. Iranian Journal of Ophthalmology. 2013; 25 (4) :284-287
URL: http://irjo.org/article-1-876-en.html
Volume 25, Issue 4 (Iranian Journal of Ophthalmology 2013) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
Persian site map - English site map - Created in 0.053 seconds with 794 queries by yektaweb 3571