Purpose:The
aim of the present study was to detect the expression of P-glycoprotein (P-gp)
and multi-drug resistance associated protein 1 (MRP1) in retinoblastoma tumors,
and analyze the relationship between its expression, the clinico-pathological
features and recurrence.
Methods:P-gp and MRP1
expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue
sections from 26 patients were studied by immunohistochemistry assay, and the
results were analyzed in correlation with clinico-pathological parameters.
Patients were classified into two groups according to their treatment: with
(n=16) and without (n=10) preoperative chemotherapy.
Results: Six (23%) and 12
(46%) tumors were P-gp and MRP1 positive respectively. Three out of five tumors
that presented P-gp had tumor invasion while MRP1 was positive in four tumors
with invasion. Seven patients showed recurrence during follow-up time that P-gp
and MRP1 were expressed in three and four of them, respectively. There was no
correlation between protein expression and clinical outcomes as recurrence in
this study.
Conclusion: MRP1 and P-gpwere intrinsically
expressed in our study population. However, the results did not demonstrate
significant association between P-gp and/or MRP1 positive expression and
unresponsiveness to chemotherapy in Iranian retinoblastoma patients.
Mirakhorli M, Ghassemi F, Asadi Amoli F. Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma. Iranian Journal of Ophthalmology. 2014; 26 (1) :17-22 URL: http://irjo.org/article-1-901-en.html