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:: Volume 26, Issue 1 (Iranian Journal of Ophthalmology 2014) ::
2014, 26(1): 17-22 Back to browse issues page
Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma
Mojgan Mirakhorli Dr., Fariba Ghassemi Dr. * , Fahimeh Asadi Amoli Dr.
, faribaghassemi@yahoo.com
Abstract:   (8529 Views)

 Purpose: The aim of the present study was to detect the expression of P-glycoprotein (P-gp) and multi-drug resistance associated protein 1 (MRP1) in retinoblastoma tumors, and analyze the relationship between its expression, the clinico-pathological features and recurrence.

 Methods: P-gp and MRP1 expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue sections from 26 patients were studied by immunohistochemistry assay, and the results were analyzed in correlation with clinico-pathological parameters. Patients were classified into two groups according to their treatment: with (n=16) and without (n=10) preoperative chemotherapy.

 Results: Six (23%) and 12 (46%) tumors were P-gp and MRP1 positive respectively. Three out of five tumors that presented P-gp had tumor invasion while MRP1 was positive in four tumors with invasion. Seven patients showed recurrence during follow-up time that P-gp and MRP1 were expressed in three and four of them, respectively. There was no correlation between protein expression and clinical outcomes as recurrence in this study.

 Conclusion: MRP1 and P-gp were intrinsically expressed in our study population. However, the results did not demonstrate significant association between P-gp and/or MRP1 positive expression and unresponsiveness to chemotherapy in Iranian retinoblastoma patients.

  

 Iranian Journal of Ophthalmology 201426(1):17-22 © 2014 by the Iranian Society of Ophthalmology

Keywords: Chemotherapy, Multi-Drug Resistance Associated Protein 1, P-glycoprotein, Retinoblastoma
Full-Text [PDF 227 kb]   (1683 Downloads)    
Type of Study: Original | Subject: Vitreoretinal
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Mirakhorli M, Ghassemi F, Asadi Amoli F. Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma. Iranian Journal of Ophthalmology. 2014; 26 (1) :17-22
URL: http://irjo.org/article-1-901-en.html


Volume 26, Issue 1 (Iranian Journal of Ophthalmology 2014) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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