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:: Volume 19, Number 3 (Iranian Journal of Ophthalmology 2007) ::
2007, 19(3): 29-33 Back to browse issues page
Aqueous Humor Nitric Oxide in Patients with Retinal Vein Occlusion
Dr. AliReza Lashay, Dr. Hooshang Faghihi, Dr. Ahmad Mirshahi, Dr. Mohammad-Sadegh Farahvash, Dr. Sasan Moghimi, Dr. AliReza Dehpour, Dr. Masood Aghsaie-Fard *
, masood219@yahoo.co.uk
Abstract:   (27048 Views)

Purpose: To investigate aqueous humor nitric oxide (NO) levels in patients with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and to compare these with age-matched controls.

Methods: Eight consecutive patients with BRVO and 16 patients with CRVO were included in this study. Aqueous humor specimens were obtained within 21 days of diagnosis. Samples of aqueous humor were also collected from 20 control patients undergoing cataract surgery. For each sample after reduction of nitrate to nitrite with vanadium chloride (VCL3), we used spectrophotometric method for simultaneous detection of nitrate and nitrite.

Results: Mean level of aqueous humor nitrite and nitrate were 84.08±21.29 μmol/l in BRVO group, 65.40±22.23 μmol/l in CRVO group, and 55.68±11.02 μmol/l in control group. The difference between aqueous humor nitrite and nitrate levels of BRVO group and that of control group was statistically significant (P<0.0001) but not for the difference between those of CRVO and control groups (P=0.10).

Conclusion: The results may support involvement of nitric oxide in the pathogenesis of BRVO.

 

Iranian Journal of Ophthalmology 200619(3):29-33
Keywords: Nitric Oxide, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion, Spectrophotometry
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Type of Study: Original | Subject: General
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Lashay A, Faghihi H, Mirshahi A, Farahvash M, Moghimi S, Dehpour A et al . Aqueous Humor Nitric Oxide in Patients with Retinal Vein Occlusion. Iranian Journal of Ophthalmology. 2007; 19 (3) :29-33
URL: http://irjo.org/article-1-146-en.html
Volume 19, Number 3 (Iranian Journal of Ophthalmology 2007) Back to browse issues page
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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