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:: جلد 20، شماره 1 - ( مجله چشم پزشکی ایران 1386 ) ::
جلد 20 شماره 1 صفحات 42-47 برگشت به فهرست نسخه ها
Comparison of the Effect of Adjuvant 5-Fluorouracil, Low Molecular Weight Heparin and Daunomycin in Combination with Triamcinolone during Vitrectomy in Advanced Retinal Detachment
دكتر احمد میرشاهی*، دكتر حبیب دژآگاه، دكتر علیرضا لاشیئی، دكتر علی طباطبایی، دكتر محمدصادق فره وش، دكتر هوشنگ فقیهی، دكتر علی عبداللهی، دكتر رضا کارخانه، دكتر مرتضی مواسات، دكتر محمد ریاضی اصفهانی
، mirshahi@tums.ac.ir
چکیده:   (19125 مشاهده)

Purpose: To compare the success rate of adjunctive 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH), and daunomycin in combination with triamcinolone during vitrectomy in eyes with retinal detachment (RD) and proliferative vitreoretinopathy (PVR).

Methods: In this prospective randomized clinical trial, 69 eyes from 69 patients with RD and PVR (grade B or C) randomized to 3 groups. Group 1: received 5-FU and LMWH (200 microgram/ml 5-FU and 5 IU/ml LMWH, Fragmin) group 2: received daunomycin (0.5 mg) in
500 cc infusion fluid and group 3: control group. In all patients, 0.1 cc intravitreal triamcinolone was used during vitrectomy. The patients visited on day 1, week 1, month 1, 3 and 6. Best corrected visual acuity (BCVA) and retinal status compared in the 3 groups.

Results: Complete data were available for 60 out of 69 patients. Thirty five patients (58.3%) were male and 25 patients (41.7%) were female. The patient age range was 19-84 years and the mean age was 49. The groups did not have significant difference in age, sex, duration of detachment, severity of PVR, preoperative visual acuity (V/A), lens status, type of tamponade and encircling band and buckle. Postoperative V/A and retina status also was the same in the 3 groups.

Conclusion: Perioperative infusion of 5-FU, LMWH and daunomycin does not significantly increase the success rate of patients with RD and PVR comparing to control group. Although visual acuity improvement and retina reattachment rate in group 1 and 2 were better than control group, but statistical analysis failed to show significant difference between the 3 groups.

 

Iranian Journal of Ophthalmology 200820(1):42-47
واژه‌های کلیدی: retinal detachment، proliferative vitreoretinopathy، daunomycin، 5-Fluorouracil، low molecular weight heparin، deep vitrectomy
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نوع مطالعه: پژوهشی | موضوع مقاله: عمومى
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Mirshahi A, Dezhagah H, Lashay A, Tabatabaei A, Farahvash M, Faghihi H, et al . Comparison of the Effect of Adjuvant 5-Fluorouracil, Low Molecular Weight Heparin and Daunomycin in Combination with Triamcinolone during Vitrectomy in Advanced Retinal Detachment. Iranian Journal of Ophthalmology. 2008; 20 (1) :42-47
URL: http://irjo.org/article-1-114-fa.html

میرشاهی احمد، دژآگاه حبیب، لاشیئی علیرضا، طباطبایی علی، فره وش محمدصادق، فقیهی هوشنگ، و همکاران. و همکاران.. Comparison of the Effect of Adjuvant 5-Fluorouracil, Low Molecular Weight Heparin and Daunomycin in Combination with Triamcinolone during Vitrectomy in Advanced Retinal Detachment. مجله چشم پزشکی ایران. 1386; 20 (1) :42-47

URL: http://irjo.org/article-1-114-fa.html



جلد 20، شماره 1 - ( مجله چشم پزشکی ایران 1386 ) برگشت به فهرست نسخه ها
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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