:: Volume 21, Issue 4 (Iranian Journal of Ophthalmology 2009) ::
2009, 21(4): 37-44 Back to browse issues page
Visual Evoked Potential Study in Multiple Sclerosis Disease
Morteza Movassat Dr. *, Niloufar Piri Dr., Mehdi Nili AhmadAbadi Dr.
, movassat456@yahoo.com
Abstract:   (17775 Views)

Purpose : To demonstrate visual evoked potential (VEP) changes in multiple sclerosis (MS) disease

Methods : A case series study of VEP changes in forty-nine patients with definite, probable and possible diagnoses of MS referred to electrophysiology ward from January 2002 to December 2005. Pattern VEP was done for those with good visual acuity (VA), and flash VEP was done for those who did not have central fixation or good VA. Characteristics of P100 wave in pattern VEP and P2 wave in flash VEP were evaluated.

Results : The implicit time of P100 and P2 waves in pattern and flash VEP, demonstrated severe abnormalities in 84.5% of definite MS. In probable MS, implicit time increased in 81.8% cases. In possible MS cases, increased implicit time was seen in more than 50% of patients. Decrease in amplitude alone, was seen in a few cases. Combined changes of implicit time and amplitude were prominent.

Conclusion : VEP is an invaluable electrophysiological test in MS for both diagnosis and follow-up of the patients. Concurrent with magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) analysis, VEP can help neurologists and ophthalmologists for better evaluation of MS patients.


Iranian Journal of Ophthalmology 200921(4):37-44 © 2009 by the Iranian Society of Ophthalmology
Keywords: Visual Evoked Potential, Multiple Sclerosis, Implicit Time, Amplitude, P100 Wave, P2 Wave
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Type of Study: Original | Subject: General

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Volume 21, Issue 4 (Iranian Journal of Ophthalmology 2009) Back to browse issues page