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:: جلد 22، شماره 4 - ( مجله چشم پزشکی ایران 1389 ) ::
جلد 22 شماره 4 صفحات 59-65 برگشت به فهرست نسخه ها
Ketoconazole in the Treatment of Central Serous Chorioretinopathy
دكتر محمد ریاضی اصفهانی، دكتر حمیدرضا ترابی*، دكتر زهرا اعلمی هرندی، دكتر محمد زارعی
، dr_hamidrezatorabi@yahoo.com
چکیده:   (14960 مشاهده)

Purpose : The aim of this study is to measure the endogenous cortisol levels in the patients with central serous chorioretinopathy (CSCR) and also, evaluate the short-term effect of oral ketoconazole in the treatment of both acute and chronic CSCR.

Methods : In this prospective interventional case series 12 patients with acute CSCR and 7 patients with chronic CSCR (Including one patient with bilateral chronic disease) were treated with oral ketoconazole 200 mg two times per day. Measurement of best corrected visual acuity (BCVA), macular thickness [Using optical coherence tomography (OCT)], and 24-hour urinary cortisol levels were done before and after one month of treatment.

Results : Abnormal elevated levels of 24-hour urinary cortisol were identified in 50% of cases at presentation and it reduced after treatment (P=0.03). In acute CSCR patients, pretreatment mean logMAR BCVA was 0.3±0.2 and improved to 0.1±0.1 after treatment (P=0.005). Also central macular thickness was significantly reduced after treatment (P=0.001). Complete or partial improvement in central macular thickness and BCVA were happened in four from eight eyes with chronic CSCR.

Conclusion : Oral ketoconazole (400 mg/day) may be a noninvasive and safe therapeutic option for patients with acute CSCR and may alter the clinical course of some patients with chronic disease.

   

Iranian Journal of Ophthalmology 201022(4):59-65 © 2010 by the Iranian Society of Ophthalmology
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نوع مطالعه: پژوهشی | موضوع مقاله: عمومى
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Riazi Esfahani M, Torabi H R, Aalami Harandi Z, Zarei M. Ketoconazole in the Treatment of Central Serous Chorioretinopathy. Iranian Journal of Ophthalmology. 2010; 22 (4) :59-65
URL: http://irjo.org/article-1-407-fa.html

ریاضی اصفهانی محمد، ترابی حمیدرضا، اعلمی هرندی زهرا، زارعی محمد. Ketoconazole in the Treatment of Central Serous Chorioretinopathy. مجله چشم پزشکی ایران. 1389; 22 (4) :59-65

URL: http://irjo.org/article-1-407-fa.html



جلد 22، شماره 4 - ( مجله چشم پزشکی ایران 1389 ) برگشت به فهرست نسخه ها
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
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