[صفحه اصلی ]   [Archive] [ English ]  
:: جلد 23، شماره 2 - ( مجله چشم پزشکی ایران 1390 ) ::
جلد 23 شماره 2 صفحات 3-10 برگشت به فهرست نسخه ها
Effects of Memantine on Visual Functions after Scleral Buckling for Retinal Detachment
دکتر محمد ریاضی اصفهانی، دکتر مهسا خاکباز، دکتر زهرا اعلمی هرندی*، دکتر علی عبداللهی، دکتر ساسان مقیمی، دکتر مرتضی مواسات
، riazifahimi@yahoo.com
چکیده:   (16469 مشاهده)

Purpose : Evaluating the effects of memantine on visual function after scleral buckling for rhegmatogenous retinal detachment (RRD)

Methods : In a Double blind prospective randomized clinical trial, 61 patients with clinical diagnosis of less than 4 weeks macula-off RRD who had successful scleral buckle surgery had been selected and divided into two randomized groups. Thirty of them received 5 mg/day memantine orally for first week and 10 mg/day for two weeks, while the others (31 patients) received placebo. Best corrected visual acuity (BCVA), macular thickness measured by optical coherence tomography (OCT) and contrast sensitivity test, were measured for all patients at one and three months. Multifocal electroretinography (ERG) was performed for all patients who returned to us at third month postoperatively.

Results : Mean BCVA was 0.74±0.27 logMAR in memantine group versus 0.77±0.21 logMAR in placebo group at one month, and improved respectively to 0.64±0.25 logMAR versus 0.69±0.26 logMAR in memantine and placebo groups. There wasn't significant difference in first month and third month BCVA between two groups. Mean central macular thickness in memantine group was significantly lower than placebo group 215±41 µm versus 262±101 µm at first month, respectively and this difference was also significant after three months 204±39 µm versus 249±57 µm. Nineteen of 61 patients (31.4%) had persistent subretinal fluid (SRF) at first month (12 of them were in placebo group). P1 wave amplitude of multifocal ERG in 10-15º and >15º of central fovea in memantine group were significantly higher than placebo group.

Conclusion : Memantine using as an adjuvant to reattachment surgery may have neuroprotective effects which can rehabilitate the function of macula in RRD patients.

 

Iranian Journal of Ophthalmology 201123(2):3-10 © 2011 by the Iranian Society of Ophthalmology
متن کامل [PDF 282 kb]   (2648 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: عمومى
ارسال پیام به نویسنده مسئول

ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Riazi Esfahani M, Khakbaz M, Aalami Harandi Z, Abdollahi A, Moghimi S, Movassat M. Effects of Memantine on Visual Functions after Scleral Buckling for Retinal Detachment. Iranian Journal of Ophthalmology. 2011; 23 (2) :3-10
URL: http://irjo.org/article-1-463-fa.html

ریاضی اصفهانی محمد، خاکباز مهسا، اعلمی هرندی زهرا، عبداللهی علی، مقیمی ساسان، مواسات مرتضی. Effects of Memantine on Visual Functions after Scleral Buckling for Retinal Detachment. مجله چشم پزشکی ایران. 1390; 23 (2) :3-10

URL: http://irjo.org/article-1-463-fa.html



جلد 23، شماره 2 - ( مجله چشم پزشکی ایران 1390 ) برگشت به فهرست نسخه ها
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 4072