[صفحه اصلی ]   [Archive] [ English ]  
:: جلد 25، شماره 2 - ( مجله چشم پزشکي ايران 1392 ) ::
جلد 25 شماره 2 صفحات 90-106 برگشت به فهرست نسخه ها
Review Article: Ocular Effects of Sulfur Mustard
دکتر یونس پناهی، دکتر مصطفی نادری، دکتر محمدعلی جوادی، دکتر زهره پورصالح*
، z_poursaleh@yahoo.com
چکیده:   (10003 مشاهده)

Purpose : To review current knowledge about ocular effects of sulfur mustard (SM) and the associated histopathologic findings and clinical manifestations

Methods : Literature review of medical articles (human and animal studies) was accomplished using PubMed, Scopus and ISI databases. A total of 274 relevant articles in English were retrieved and reviewed thoroughly.

Results : Eyes are the most sensitive organs to local toxic effects of mustard gas. Ocular injuries are mediated through different toxic mechanisms including: biochemical damages, biomolecular and gene expression modification, induction of immunologic and inflammatory reactions, disturbing ultrastructural architecture of the cornea, and long-lasting corneal denervation. The resulting ocular injuries can roughly be categorized into acute or chronic complications. Most of the patients recover from acute injuries, but a minority of victims will suffer from chronic ocular complications. Mustard gas keratopathy (MGK) is a devastating late complication of SM intoxication that proceeds from limbal stem cell deficiency (LSCD).

Conclusion : SM induces several different damaging changes in case of ocular exposure hence leading to a broad spectrum of ocular manifestations in terms of severity, timing and form. Unfortunately, no effective strategy has been introduced yet to inhibit or restore these damaging changes.

 

Iranian Journal of Ophthalmology 201325(2):90-106 © 2013 by the Iranian Society of Ophthalmology

متن کامل [PDF 404 kb]   (2681 دریافت)    
نوع مطالعه: مروری | موضوع مقاله: سگمان قدامی
ارسال پیام به نویسنده مسئول

ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Panahi Y, Naderi M, Zare M A, Poursaleh Z. Review Article: Ocular Effects of Sulfur Mustard. Iranian Journal of Ophthalmology. 2013; 25 (2) :90-106
URL: http://irjo.org/article-1-807-fa.html

پناهی یونس، نادری مصطفی، جوادی محمدعلی، پورصالح زهره. Review Article: Ocular Effects of Sulfur Mustard. مجله چشم پزشکی ایران. 1392; 25 (2) :90-106

URL: http://irjo.org/article-1-807-fa.html



جلد 25، شماره 2 - ( مجله چشم پزشکي ايران 1392 ) برگشت به فهرست نسخه ها
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4072