[صفحه اصلی ]   [Archive] [ English ]  
:: جلد 26، شماره 1 - ( مجله چشم پزشکي ايران 1393 ) ::
جلد 26 شماره 1 صفحات 17-22 برگشت به فهرست نسخه ها
Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma
دکتر مژگان میرآخورلی، دکتر فریبا قاسمی*، دکتر فهیمه اسدی آملی
، faribaghassemi@yahoo.com
چکیده:   (10007 مشاهده)

 Purpose: The aim of the present study was to detect the expression of P-glycoprotein (P-gp) and multi-drug resistance associated protein 1 (MRP1) in retinoblastoma tumors, and analyze the relationship between its expression, the clinico-pathological features and recurrence.

 Methods: P-gp and MRP1 expression in formalin-fixed paraffin-embedded retinoblastoma bearing ocular tissue sections from 26 patients were studied by immunohistochemistry assay, and the results were analyzed in correlation with clinico-pathological parameters. Patients were classified into two groups according to their treatment: with (n=16) and without (n=10) preoperative chemotherapy.

 Results: Six (23%) and 12 (46%) tumors were P-gp and MRP1 positive respectively. Three out of five tumors that presented P-gp had tumor invasion while MRP1 was positive in four tumors with invasion. Seven patients showed recurrence during follow-up time that P-gp and MRP1 were expressed in three and four of them, respectively. There was no correlation between protein expression and clinical outcomes as recurrence in this study.

 Conclusion: MRP1 and P-gp were intrinsically expressed in our study population. However, the results did not demonstrate significant association between P-gp and/or MRP1 positive expression and unresponsiveness to chemotherapy in Iranian retinoblastoma patients.

  

 Iranian Journal of Ophthalmology 201426(1):17-22 © 2014 by the Iranian Society of Ophthalmology

متن کامل [PDF 227 kb]   (1870 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: ویتره و رتین
ارسال پیام به نویسنده مسئول

ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mirakhorli M, Ghassemi F, Asadi Amoli F. Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma. Iranian Journal of Ophthalmology. 2014; 26 (1) :17-22
URL: http://irjo.org/article-1-901-fa.html

میرآخورلی مژگان، قاسمی فریبا، اسدی آملی فهیمه. Association between P-glycoprotein and Multi-Drug Resistance Associated Protein 1 Expression and Clinical Outcomes in Iranian Retinoblastoma. مجله چشم پزشکی ایران. 1393; 26 (1) :17-22

URL: http://irjo.org/article-1-901-fa.html



جلد 26، شماره 1 - ( مجله چشم پزشکي ايران 1393 ) برگشت به فهرست نسخه ها
مجله چشم پزشکی ایران Iranian Journal of Ophthalmology
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 4075